David M. Kristensen*, R. Matthew Ward*, Andreas Martin Lisewski, Serkan Erdin, Brian Y. Chen, Viacheslav Y. Fofanov, Marek Kimmel, Lydia E. Kavraki, and Olivier Lichtarge. (2007). "Prediction of Enzyme Function Based on 3D Templates of Evolutionarily Important Amino Acids". BMC Bioinformatics. (Accepted).
*These authors contributed equally to this work.
|
Protein |
E.C. # |
SCOP Class |
SCOP Fold |
Function |
|
1rie_ |
1.10.2.2 |
b |
ISP domain |
RIESKE IRON-SULFUR PROTEIN |
|
1mgtA |
2.1.1.63 |
a,a/b |
DNA/RNA-binding 3-helical bundle Ribonuclease H-like motif |
O6-METHYLGUANINE-DNA METHYLTRANSFERASE |
|
1eg2A |
2.1.1.72 |
a/b |
S-adenosyl-L-methionine-dependent methyltransferases |
MODIFICATION METHYLASE RSRI |
|
7mhtA |
2.1.1.73 |
a/b |
S-adenosyl-L-methionine-dependent methyltransferases |
CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI |
|
1jg1A |
2.1.1.77 |
a/b |
S-adenosyl-L-methionine-dependent methyltransferases |
PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE |
|
1kpgA |
2.1.1.79 |
a/b |
S-adenosyl-L-methionine-dependent methyltransferases |
CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 |
|
1inlB |
2.5.1.16 |
a/b |
S-adenosyl-L-methionine-dependent methyltransferases |
SPERMIDINE SYNTHASE |
|
1g64B |
2.5.1.17 |
a/b |
P-loop containing nucleoside triphosphate hydrolases |
COB(I)ALAMIN ADENOSYLTRANSFERASE |
|
1e6bA |
2.5.1.18 |
a,a/b |
Glutathione S-transferase (GST), C-terminal domain Thioredo |
GLUTATHIONE S-TRANSFERASE |
|
1f2eA |
2.5.1.18 |
a,a/b |
Glutathione S-transferase (GST), C-terminal domain Thioredo |
GLUTATHIONE S-TRANSFERASE |
|
1gsfA |
2.5.1.18 |
a,a/b |
Glutathione S-transferase (GST), C-terminal domain Thioredo |
GLUTATHIONE TRANSFERASE A1-1 |
|
6gsvA |
2.5.1.18 |
a,a/b |
Glutathione S-transferase (GST), C-terminal domain Thioredo |
MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3 |
|
1bdyA |
2.7.1.37 |
b |
PH domain-like |
PROTEIN KINASE C |
|
1iasA |
2.7.1.37 |
small |
Cystine-knot cytokines |
TGF-BETA RECEPTOR TYPE I |
|
1qf8A |
2.7.1.37 |
b |
Galactose-binding domain-like |
CASEIN KINASE II |
|
1rgs_ |
2.7.1.37 |
b |
C2 domain-like |
|
|
1b55B |
2.7.1.112 |
a+b |
Protein kinase-like (PK-like) |
TYROSINE-PROTEIN KINASE BTK |
|
1fltW |
2.7.1.112 |
small |
Rubredoxin-like |
VASCULAR ENDOTHELIAL GROWTH FACTOR |
|
1nukA |
2.7.1.112 |
|
|
TYROSINE-PROTEIN KINASE RECEPTOR EPH |
|
1nksA |
2.7.4.3 |
a/b |
P-loop containing nucleoside triphosphate hydrolases |
ADENYLATE KINASE |
|
1nskL |
2.7.4.6 |
a+b |
Ferredoxin-like |
NUCLEOSIDE DIPHOSPHATE KINASE |
|
1jxiA |
2.7.4.7 |
a/b |
Ribokinase-like |
PHOSPHOMETHYLPYRIMIDINE KINASE |
|
1c25_ |
3.1.3.48 |
a/b |
Rhodanese/Cell cycle control phosphatase |
CDC25A |
|
1gwz_ |
3.1.3.48 |
a/b |
(Phosphotyrosine protein) phosphatases II |
SHP-1 |
|
1j4xA |
3.1.3.48 |
a/b |
(Phosphotyrosine protein) phosphatases II |
DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 |
|
1cen_ |
3.2.1.4 |
b,a/b |
WW domain-like TIM beta/alpha-barrel FKBP-like |
CELLULASE CELC |
|
1edg_ |
3.2.1.4 |
b |
Single-stranded right-handed beta-helix |
ENDOGLUCANASE A |
|
2nlrA |
3.2.1.4 |
a+b |
Lysozyme-like |
ENDOGLUCANASE |
|
7a3hA |
3.2.1.4 |
a+b |
Lysozyme-like |
ENDOGLUCANASE |
|
1i8a_ |
3.2.1.8 |
b |
6-bladed beta-propeller |
ENDO-1,4-BETA-XYLANASE A |
|
1ukrA |
3.2.1.8 |
a/b |
TIM beta/alpha-barrel |
ENDO-1,4-B-XYLANASE I |
|
1goiA |
3.2.1.14 |
a/b |
TIM beta/alpha-barrel |
CHITINASE B |
|
1czfA |
3.2.1.15 |
b |
Concanavalin A-like lectins/glucanases |
POLYGALACTURONASE II |
|
1d9uA |
3.2.1.17 |
a/b |
TIM beta/alpha-barrel |
BACTERIOPHAGE LAMBDA LYSOZYME |
|
3lzt_ |
3.2.1.17 |
|
|
LYSOZYME |
|
1f8eA |
3.2.1.18 |
b |
Concanavalin A-like lectins/glucanases |
NEURAMINIDASE |
|
1fr6A |
3.5.2.6 |
mult |
beta-lactamase/transpeptidase-like |
BETA-LACTAMASE |
|
1k55A |
3.5.2.6 |
mult |
beta-lactamase/transpeptidase-like |
BETA LACTAMASE OXA-10 |
|
1pioA |
3.5.2.6 |
mult |
beta-lactamase/transpeptidase-like |
BETA-LACTAMASE |
|
1juk_ |
4.1.1.48 |
a/b |
TIM beta/alpha-barrel |
INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE |
|
1ayl_ |
4.1.1.49 |
|
|
PHOSPHOENOLPYRUVATE CARBOXYKINASE |
|
1jl0B |
4.1.1.50 |
a+b |
S-adenosylmethionine decarboxylase |
S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME |
|
2ahjA |
4.2.1.84 |
a+b |
Nitrile hydratase alpha chain |
NITRILE HYDRATASE |
|
1dcpA |
4.2.1.96 |
a+b |
DCoH-like |
DCOH |
|
1ep0A |
5.1.3.13 |
b |
Double-stranded beta-helix |
DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE |
|
1eq2H |
5.1.3.20 |
a/b |
NAD(P)-binding Rossmann-fold domains |
ADP-L-GLYCERO-D-MANNOHEPTOSE 6-EPIMERASE |
|
1a41_ |
5.99.1.2 |
a+b |
DNA breaking-rejoining enzymes |
TOPOISOMERASE I |
|
1cy4A |
5.99.1.2 |
mult |
Prokaryotic type I DNA topoisomerase |
DNA TOPOISOMERASE I |
|
1ej9A |
5.99.1.2 |
a+b,mult |
DNA breaking-rejoining enzymes Eukaryotic DNA topoisomerase |
DNA TOPOISOMERASE I |
|
1vcc_ |
5.99.1.2 |
a+b |
DNA topoisomerase I domain |
DNA TOPOISOMERASE I |
|
1fpmA |
6.3.4.3 |
a/b |
P-loop containing nucleoside triphosphate hydrolases |
FORMATE--TETRAHYDROFOLATE LIGASE |
|
1dj3A |
6.3.4.4 |
a/b |
P-loop containing nucleoside triphosphate hydrolases |
ADENYLOSUCCINATE SYNTHETASE |
|
1k92A |
6.3.4.5 |
a/b,a+b |
Adenine nucleotide alpha hydrolase-like Argininosuccinate s |
ARGININOSUCCINATE SYNTHASE |
|
Protein |
E.C. # |
SCOP Class |
SCOP Fold |
Function |
|
1hdoA |
1.3.1.24 |
a/b |
NAD(P)-binding Rossmann-fold domains |
BILIVERDIN IX BETA REDUCTASE |
|
1b26A |
1.4.1.3 |
a/b |
NAD(P)-binding Rossmann-fold domains |
GLUTAMATE DEHYDROGENASE |
|
1kmvA |
1.5.1.3 |
a/b |
Dihydrofolate reductases |
DIHYDROFOLATE REDUCTASES, EUKARYOTIC TYPE |