skip to content »

Lichtarge Computational Biology Lab

Houston, Texas

Lichtarge Computational Biology Lab
Lichtarge Computational Biology Lab
not shown on screen

Evolutionary Trace Server

    The Evolutionary Trace is available for use on our server via two front-end programs that provide different means of running a trace and viewing results. Please see the linked pages for more information on these programs.

    Evolutionary Trace report_maker

    The Evolutionary Trace report_maker is the easiest way to access the Evolutionary Trace to find out information about functional residues. It pools information from different sources about protein sequence, structure and elementary annotation and to that background superimposes inference about evolutionary behavior of individual residues using the real-valued evolutionary trace method. It takes a Protein Data Bank identifier or an UniProt accession number as its only input and returns a human-readable document in PDF format, supplemented by the original data needed to produce the results quoted in the report.

    Evolutionary Trace Viewer

    The Evolutionary Trace Viewer contains the ET Wizard, which allows the user to run a trace by providing only a PDB code, or more complex traces using custom alignments, phylogenetic trees, and other advanced parameters. Users can then use the program to interactively view ET results, with functional residues mapped onto a protein structure in a molecular graphics display. The Evolutionary Trace Viewer also provides a multiple sequence alignment viewer and a phylogenetic tree viewer to allow the reader to examine the input to the ET algorithm.