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Lichtarge Computational Biology Lab

Houston, Texas

Lichtarge Computational Biology Lab
Lichtarge Computational Biology Lab
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Evolutionary Action

Enter UniProt accession number (e.g. Q1RMC1) or gene name:

Enter a substitution (e.g. "M1A"):

Follow this link to view hEAt scores.

Follow this link to view the correlation between Evolutionary Action and experimental impact under several assays.


Katsonis P, Lichtarge O.
"A formal perturbation equation between genotype and phenotype determines the evolutionary action of protein coding variations on fitness."
Genome Res. 2014 Sep 12. pii: gr.176214.114. PMID: 25217195

To run an Evolutionary Trace analysis with more options, visit uet.

Important note: The services and data in this website are intended for research purposes only, not for clinical and diagnostic use.