Difference Evolutionary Trace Server for G Protein-Coupled Class A Receptors
Select a superfamily :
--superfamily choices--
ClassA_2512 (2512 sequences)
ClassA_5105 (5105 sequences)
All_Rhodopsin (465)
All_Amine (547)
All_Amine402 (402)
Melatonin (22)
Prostanoid (89)
EDG (161)
Cannabinoid (24)
Adenosine (55)
All_Peptide (938)
Chemokine (305)
Nucleotide_like (148)
Gonadotropin_releasing_hormone (62)
Follicle_stimulating_hormone (102)
Mas_oncogene_related (78)
All_Olfactory (2279)
Select a subfamily :
--subfamily choices--
Rhodopsin
-All_Rhodopsin (465 sequences)
-Opsin_Vertebrate (316)
-Opsin_Arthropod (70)
-Opsin_Mollusc (8)
-Opsin_other (70)
Amine
-All_Amine (547)
-All_Amine402 (402)
-Dopamine (91)
-Dopa_type2-3-4 (45)
-Histamine (47)
-Muscarinic_acetylcholine (65)
-Adrenoceptor (118)
-Adrenoceptor_alpha (71)
-adr_alpha1 (31)
-adr_alpha2 (40)
-Adrenoceptor_beta (47)
-Serotonin (131)
-Serotonin_type1 (51)
-Serotonin_type2 (30)
-Octopamine (26)
-Traceamine (69)
Melatonin
-Melatonin (22)
Prostanoid
-Prostanoid (89)
Cannabinoid
-Cannabinoid (24)
Lysosphingolipid & LPA (EDG)
-EDG (161)
-Sphingosine-EDG (117)
-Lysophosphatidic_acid-EDG (44)
Peptide
-All_Peptide (938)
-Angiotensin (34)
-Chemokine (305)
-Chemo_CCR (226)
-Chemo_CXC (65)
-Melanocortin (256)
-NeuropeptideY (74)
-Opioid (54)
-Somatostatin (34)
-Tachykinin (44)
-Vasopressin (54)
Nucleotide_like
-Nucleotide_like (148)
-Adenosine (55)
-Purinoceptor (103)
Viral
-Viral (81)
glycoprotein-hormone
-Gonadotropin_releasing_hormone (62)
-Follicle_stimulating_hormone (102)
Mas-related
-Mas_oncogene_related (78)
Olfactory
-All_Olfactory (2279)
-OlfactoryII_1 (157)
-OlfactoryII_2 (256)
-OlfactoryII_4 (260)
-OlfactoryII_5 (346)
-OlfactoryII_6 (141)
-OlfactoryII_7 (82)
-OlfactoryII_8 (218)
-OlfactoryII_9 (44)
-OlfactoryII_10 (185)
-OlfactoryII_13 (72)
-OlfactoryI_51-52 (264)
-Olfactory_FOR-like (257)
Rodriguez et al. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7789-92. PMID: 20385837
Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors.
PNAS Abstract [PDF ] .
Madabushi et al. J. Biol. Chem. 2004 279(9): 8126-32 PMID: 14660595
Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions
[Abstract] .
[PDF ] .
Representative GPCR ClassA phylogenetic tree